
Also called: B12 test, Cobalamin test, B12 blood test
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What it checks
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Serum Vitamin B12 measures the level of vitamin B12 in the blood, an essential nutrient required for red blood cell formation, DNA synthesis, and nerve function. Deficiency can cause megaloblastic anemia, neuropathy, cognitive changes, and fatigue.
Vitamin B12 is primarily obtained from animal-based foods, making deficiency common among vegetarians, elderly individuals, and those with absorption disorders.
This test is advised to:
Diagnose anemia
Evaluate nerve symptoms like tingling or numbness
Investigate fatigue or memory issues
Monitor supplementation therapy
Assess malabsorption disorders
Low B12 affects nerve myelination and red blood cell production. Prolonged deficiency can lead to irreversible neurological damage if untreated.
Persistent fatigue
Numbness or tingling
Poor concentration
Pale skin
Glossitis (inflamed tongue)
Fasting may be advised
Inform about supplements or injections
Normal: 200–900 pg/mL
Low: Nutritional deficiency or malabsorption
High: Excess supplementation or liver disease
Can vegetarians develop deficiency? Yes, vegetarians and vegans are at higher risk of developing B12 deficiency because the vitamin is mainly found in animal products like meat, eggs, and dairy; fortified foods or supplements are often necessary to prevent symptoms like fatigue and anemia.
Is nerve damage reversible? Yes, in early stages nerve damage from B12 deficiency is often reversible with prompt supplementation and dietary changes, but prolonged deficiency can lead to permanent neurological issues like neuropathy, so early testing and treatment are crucial.
Is fasting required? Fasting is often recommended for accurate serum B12 testing to avoid any potential interference from recent meals, though it's not always strictly mandatory—consult your doctor for specific instructions based on your situation.
Can folate mask B12 deficiency? Yes, high folate intake (from supplements or fortified foods) can mask a B12 deficiency by correcting the anemia symptoms while allowing neurological damage to progress undetected, so both vitamins should be tested together if deficiency is suspected.
How often should levels be checked? Levels should be checked as advised by your doctor, typically every 3–6 months for those on supplementation or with absorption issues, or annually for at-risk groups like vegetarians to monitor and prevent deficiency-related complications.
The Vitamin B12 test checks a vitamin your nerves and blood cells need. It is often advised if:
Tapadia Diagnostic Centre in Bengaluru offers NABL-accredited Vitamin B12 Test test from a Blood sample(s). B12 test, Cobalamin test, B12 blood test is also prescribed for Fatigue, numbness, memory loss, balance issues. Established in 1989, this doctor-led diagnostic centre ensures high accuracy. Home sample collection and walk-in facility available at our Bengaluru center. Pay at the centre with no advance payment. Book online or visit us.
Vitamin B12 Test in Bengaluru
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